Comment on “Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of Human Bronchial Epithelial Cells and Promotes Tumor Formation”
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Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of Human Bronchial Epithelial Cells and Promotes Tumor Formation
Epidemiological studies suggest that living near mountaintop coal mining (MTM) activities is one of the contributing factors for high lung cancer incidence. The purpose of this study was to investigate the long-term carcinogenic potential of MTM particulate matter (PMMTM) exposure on human bronchial epithelial cells. Our results show that chronic exposure (3 months) to noncytotoxic, physiologic...
متن کاملCorrection to Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of Human Bronchial Epithelial Cells and Promotes Tumor Formation
In the version of this article originally published, the statement under Materials and Methods “In comparison with PMCON, Si and Mo were found to be the main inorganic chemical elements in PMMTM with the % weight-average of 48.15 ± 26.91% and 28.90 ± 4.16%, respectively, for Si and Mo versus 23.75 ± 15.07% and 0.00 ± 0.00% of the elements in PMCON” should be modified to “In comparison with PMCO...
متن کاملChronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung Epithelial Cells
Nickel is a well-known human lung carcinogen with the particulate form being the most potent; however, the carcinogenic mechanism remains largely unknown. Few studies have investigated the genotoxicity and carcinogenicity of nickel in its target cell, human bronchial epithelial cells. Thus, the goal of this study was to investigate the effects of particulate nickel in human lung epithelial cell...
متن کاملCumulative impacts of mountaintop mining on an Appalachian watershed.
Mountaintop mining is the dominant form of coal mining and the largest driver of land cover change in the central Appalachians. The waste rock from these surface mines is disposed of in the adjacent river valleys, leading to a burial of headwater streams and dramatic increases in salinity and trace metal concentrations immediately downstream. In this synoptic study we document the cumulative im...
متن کاملMechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells.
Carcinogenesis is a multistage process with sequences of genetic events that govern the phenotypic expression of a series of transformation steps that lead to the development of metastatic cancer. To better understand the mechanisms involved in human bronchial carcinogenesis induced by alpha particles from radon, we have developed a model of neoplastic transformation based on human papillomavir...
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ژورنال
عنوان ژورنال: Environmental Science & Technology
سال: 2015
ISSN: 0013-936X,1520-5851
DOI: 10.1021/acs.est.5b01781